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A split-second mistake brings Nicky a whole lot closer to Zav than she bargained for. Meanwhile, a troubling discovery causes Roxanna to question her loyalties. And Dom is forced to make a choice between sacrificing an opportunity and letting down Lofty.

The party celebrating 70 years of the NHS is put on hold when a major incident pushes Holby to the limits. Serena is reminded of a patient she saved many years ago - with the odds stacked against her, and withRic's help, can she do the same again? Jac and Abigail find themselves at odds over a patient set for a heart transplant. But with Jac back at work, is the transplant Abigail's only concern? Sheilagh reflects on her stay at Holby and the importance of the NHS. Encouraged by Dom's feelings for her grandson, she gives Lofty one last present before she goes.

Torn between a chance to make history and her conscience, Roxanna faces a tough decision. Will she cross the line? Hanssen's recovery is put to the test with Essie's arrival, but he'll have to overcome painful memories if he wants to save her life. When Donna's hopes for her family seem out of reach, Zav is the last person she expects to save the day - has she misjudged him?

When nothing else seems to be going Sacha's way, he tries his hand at a new romance. Meanwhile, tensions rise as Meena moves in on Nicky's turf up on Darwin. And unconvinced by his slippery charm, Donna puts Zav to the test.

Jac is back on form after her surgery and determined to prove she is a doctor and not a patient. Dom and Lofty find themselves at cross purposes, which puts their future in the balance. Elsewhere, Essie sees Holby afresh through the eyes of a patient.

A stressful day for Fletch gets worse when one of his kids is injured, and then a face from his past turns up. Meanwhille, Hanssen attempts to express his feelings to Roxanna, and Serena and Ric decide to teach Nicky and Meena a little humility.

Fletch clashes with estranged father Steven when Evie demands they let him back into their lives, while Essie is determined to help Josh after discovering he was an applicant for Gaskell's Project Laszlo. Dominic fears for his compatibility with Lofty after a contagious incident on AAU shows they are not thinking the same way.

Roxanna questions Gaskell's leadership when his focus seems off. Can they work together to save a patient's life, or is the the trust between them fractured forever? Troubled Fletch throws himself into work as a distraction. When his micro-managing of Nicky puts a scared patient at risk, can Fletch find a way to forgive himself in time to put things right? Overworked and underappreciated, Serena is in no mood for games when a porters' prank goes awry. But is her short fuse making Serena too quick to judge?

A conflicted Essie faces a dilemma when trial patient Josh's condition deteriorates, and Donna clashes with Xavier when she accuses him of not taking their beauty business seriously. Elsewhere, Meena tries to stay positive when her day goes from bad to worse.

A special episode focusing on male mental health. Long-serving Dr Sacha Levy struggles with his emotions after a devastating surgical outcome for a favourite patient. The episode departs from Holby's usual format, exploring previously shown scenes from a new perspective, as the shattered consultant looks back at a testing year at Holby.

Hanssen tries to bury himself in his work, but when Gaskell makes a move he hadn't bargained for, he can no longer ignore his conscience. Fletch is burning the candle at both ends, leaving Evie to pick up the slack. Desperate to make things right with his daughter, Fletch faces a tough decision, while an isolated Meena turns to an old flame for comfort.

An unexpected new friendship helps Frieda find her way and Meena hits a new low, finding herself friendless and under mounting pressure from all directions, while tensions between Roxanna and Gaskell finally come to a head.

While scrambling to save a life, Hanssen and Gaskell recall the earliest days of their friendship, when a fateful encounter with a wide-eyed but driven Roxanna changed the course of all their lives forever. Under increased scrutiny and immense pressure, Gaskell wrestles with his conscience.

Hanssen holds a fretful bedside vigil at the hospital, while Gaskell wrestles with his conscience over what he's done. Fletch is missing Evie and angrily blames Steven for pulling his family apart. Sacha tentatively steps back into Holby after time off for his depression - and finds an unexpected source of support in Frieda.

As the hospital reels from tragic news, Sacha takes on a marathon operation, but Dom is concerned that he is attempting to do too much too soon. Serena is pulled in all directions when Leah, a new junior doctor, struggles with a problematic first patient, while Fletch feels he should spend some quality time with his dad after Steven's heroics while helping Mikey.

Xavier's secrets are laid bare when his wounded grandfather arrives on AAU. Gaskell's increasingly erratic behaviour puts a patient at risk, leaving Hanssen troubled. Serena tries to put some professional distance between herself and Leah.

With Hanssen inching closer to the truth, Gaskell fears exposure. Jac discovers Steven has been keeping a potentially life-changing secret from Fletch, and with Xavier continuing to distance himself from friends, Donna tries to repair his broken bonds with his family. But does Xavier really want her help?

Fletch finally confronts Jac over their feelings for each other. The death of a patient leads Jason to make a life-changing decision. Eager to protect his relationship with Dom, Lofty hides his true feelings about their future.

A tricky case causes Xavier to lose his cool with Jason, while Jac and Fletch do their awkward best to avoid each other. Elsewhere, Lofty, Meena and Leah confront their problems after being thrown together.

The lines between past and present blur as Hanssen tries to bring the hospital back from the brink. Gaskell's descent into chaos leaves Jac fearing for her life, and Meena's crusade for truth faces a set-back when she loses the only ally she had left.

With Gaskell's dastardly invention inside her, Jac fears for her life - but the only one who can remove this ticking time bomb is the man himself. Can she convince him to try? Meena throws caution to the wind and outs Gaskell's nefarious deeds, enlisting Essie's help in unravelling his web of lies.

Fletch and Sacha race against the clock, even calling on some familiar faces for help in Jac's hour of need. Meanwhile, Hanssen is determined to bury Gaskell's legacy, but is forced to unlock its final secret. And Donna is driven to make sense of her relationship with Xavier when he takes his personal pressures out on Jason.

Serena fights chaos on the ward during a hospital inspection as Meena grapples with a momentous decision. Nicky goes all out to impress Mo and prove she deserves her place on Darwin. Meanwhile, Hanssen's wounds remain raw as he tries to lock Gaskell and his crimes in the past.