Seasons & episodes

An in depth look at the complexities of the case against the woman branded as America’s first female serial killer. Questions still revolve around her claim of self-defense and whether or not she got the justice she deserved.

In 1997, the frustrated wife of a multi-millionaire convinced her lesbian lover to kill her husband. Her fatal mistake was instead of embracing here partner in crime she ditched the Sapphic spouse slayer soon after the crime.

Virginia Larzelere's husband Norman was a successful Daytona Beach dentist, and they enjoyed a beautiful home, expensive cars, a yacht, and an airplane. But the good times came to an abrupt end on March 8, 1991, when a masked gunman broke into Norman's office and killed him with a shotgun blast to the chest.

Few smiles were brighter than those of two married dentists, who shared a thriving practice and a seemingly perfect marriage. But that changed in July of 2003, when the wife began to suspect her husband was having an affair with his secretary.

Russian émigré Elena Kiejliches was living the American dream. At 36, she had two children, a millionaire husband, and a sprawling mansion in Staten Island's upscale Toldt Hill neighborhood. But Elena's fairytale life came crashing down in March 2000, when her husband, Borys, went missing.

A bright and bubbly surgical technician led a comfortable middle-class existence with her husband. But this sunny, suburban image vanished in smoke and flame on Valentine's weekend of 1998 when they went on a romantic getaway meant to rekindle their marriage, at a golf resort on Maryland's Eastern Shore.

A woman who always had a thing for hunky men married a Long Island gym owner in 1998, and everyone thought it was the perfect match. She just had one small problem with her new husband - his crack cocaine addiction.

An over-achieving real estate developer and aspiring politician was the wife of a respected urologist in the upscale D.C. suburb of Potomac, MD. In 1994, she made a run to be the Republican nominee for the U.S. Senate, but lost, partly due to a local attorney who dogged the campaign with allegations of shady business deals. Soon after, her husband and the local attorney are murdered.

A 24-year-old young woman went from rags to riches when she met and married a Miami construction millionaire in 1981. Together, the couple lived lavishly in an exclusive Coconut Grove mansion, went skiing at their Steamboat Springs ranch, and partied all night long at Stan's Miami nightclub. Then one night, the pampered trophy wife's husband is killed in a home invasion robbery.

A middle-class Houston housewife married to a successful salesman, was a stay-at-home mom raising two adorable young children in their suburban home. But then, in January of 2003, he mysteriously disappeared.

Engaged high school sweethearts met in 1991 as volunteers in the Texas Civil Air Patrol. She was an honor roll student bound for Annapolis, and he was a track star with an appointment to the Air Force Academy. This former Navy cadet was just 19 when she learned he had cheated on her. Her rival ends up dead but who did it?

A spunky and ambitious toxicologist at the San Diego medical examiner's office was a summa cum laude graduate of San Diego State University. Her husband worked for an up-and-coming biotech firm. Well-educated, highly intelligent, and good-looking, their future seemed limitless. So why did the husband commit suicide, or did he?

The female bookkeeper and business manager of a millionaire Texan entrepreneur was also a close confidant of his wife. They were so close that he, and others, began to suspect that the pair were more than just friends. Then, the entrepreneur husband was poisoned.

A millionaire heiress landed a job teaching computer science where she met and began an illicit affair with a popular sixth grade teacher. Then, the married man's wife was murdered, but who committed such a brutal act?

Did twin sisters Peggy Lowe and Betty Wilson hire a hit man to kill Betty's husband, Dr. Jack Wilson? Could the hit man's testimony be believed?

They were the perfect suburban couple. She was a trained mortician; he was a high-flying Delta Airlines pilot with a sky-high salary. They had a beautiful home in upscale Covington, KY, and two young sons. However, when he was away with work, she was having an affair. When her husband was found dead in their basement, she was the prime suspect. But was the churchgoing housewife really capable of murder?

A woman spent years campaigning for her husband, a brilliant scientist, to be allowed to leave the Soviet Union and, eventually, they were able to live freely together in the US. However, in April 1996, police discover garbage bags full of the husband's body parts being thrown into the Passaic River in New Jersey. His wife is the prime suspect for the crime.

When a Michigan salvage magnate was shot dead, police suspected a robbery gone bad; however, the investigation begins to indicate that all may not be as it seems, and soon the evidence leads the police to an internet chat room.

The body of a successful attorney is discovered lying in a shallow grave in a Sacramento winery, his wife Elisa is suspected of the crime. Before police can interview his wife, she flees the scene and commits suicide. Did guilt drive her to death?

An Albuquerque County Commissioner is shot in his own basement after being mistaken for an intruder by his wife. It was an open and shut case until investigators discovered that her first husband met a very similar fate.

In November 2001, a wealthy Virginian farmer, heir to the DuPont farms, died in his bed and authorities assumed he had a heart attack, but an autopsy revealed massive amounts of drugs. Did his wife, a hospice nurse, kill him?

After a husband was shot dead in their driveway, his wife, an Oklahoma City Baptist Sunday school teacher, was a grieving widow. Soon, an illicit affair with an insurance salesman and an insurance scam are uncovered.

A former beauty queen is married to an older, wealthy heart surgeon. In May 2001, she wakes up next to her dead husband's body and becomes the prime suspect. Did she administer the lethal cocktail of drugs, etomidate and atricurium, that killed her husband?

A sexy little Las Vegas siren with a taste for rich men snares a wealthy sports bookie. When a Las Vegas bookie went missing, his pretty girlfriend claimed he was in trouble with the mob. However, when his body is found in the desert, police believe that his girlfriend may have had a hand in both his death and his wallet.